This brief discusses the intersection between two populations—system-involved youth and runaway and homeless youth. It cites data from interviews with 654 runaway and homeless youth in 11 cities that show nearly 78 percent of the participants had at least one interaction with law enforcement. According to the Coalition for Juvenile Justice (CJJ), many of the offenses committed are considered “survival crimes,” such as trespassing to seek shelter or stealing to get food. These young people may also experience exploitation in commercial sexual or labor trafficking. Conversely, youth involved in the juvenile justice system may experience homelessness after they are released because of family discord or housing restrictions. The brief outlines CJJ’s 10 Principles of Change, which are adapted from a larger publication produced in collaboration with the National Network for Youth and the National League of Cities Institute for Youth, Education, and Families.