This brief provides background information about how girls experiencing homelessness often become involved with the juvenile justice system. For instance, girls are arrested and charged more often for status offenses than boys. Furthermore, girls are more likely to be arrested and detained for charges of running away from home than their male counterparts. The brief also summarizes the prevalence and types of abuse and exploitation experienced by girls in the home and on the street. The Coalition for Juvenile Justice emphasizes the need for stakeholders to develop gender-responsive support and practices for girls and offers recommendations for juvenile justice and homeless youth-serving agencies.