Studies have focused on the relationship between a sense of meaning in life and mental health in adults; this relationship has yet to be explored in children. The current study aimed to explore the possible relationship between meaning and mental health and behavior. Participants were recruited through Canadian schools and places of worship. Data were collected from 62 children ages 6–12 through two online, anonymous, video-based questionnaires. Regression and correlational analyses determined that a child’s sense of meaning (“meaning mindset”) was associated with self-reported mental health and positive behavior. Results showed that meaning significantly predicted mental health and positive behavior (β = .90, p < .001), accounting for 50% of the variance. The frequency with which a child attended a religious institution was not related to mental health or meaning. Future studies should continue to explore the relationship between meaning mindset and childhood well-being, while also exploring methods to foster its growth. The results of this study highlight the importance of using meaning-based approaches in both treating mental illness in children as well as in preventing it. Meaning measures could also be used to determine which children may be at risk for difficulties.