This report from the Aspen Institute explores the potential for using entrepreneurship to engage and create pathways for opportunity youth, by examining existing entrepreneurship programs and sharing emerging models for creating and adapting entrepreneurship programming targeted to the specific needs and aspirations of opportunity youth. The authors profile three sites (Del Norte County, California; Philadelphia; and San Francisco), which are part of the Youth Entrepreneurship Fund. This fund supports collaborative approaches to explore entrepreneurship as a pathway to economic self-determination and economic equity. (author abstract modified)