The National Alliance to End Homelessness and its partners assembled a group of expert practitioners, known as the Practice Knowledge Project, to discuss the most effective interventions to prevent youth homelessness from their experience in the field. This brief provides lessons learned about serving unaccompanied minor youth. The project recommends the following: 1) prevent homelessness by strengthening family, school, and community structures to support youth; 2) quickly provide crisis intervention services and assessment to recently homeless youth; 3) refer to longer-term housing and services for minor youth who cannot immediately return home or to extended family.