The National Alliance to End Homelessness and its partners assembled a group of expert practitioners, known as the Practice Knowledge Project, to discuss the most effective interventions to prevent youth homelessness from their experience in the field. This brief provides lessons learned about serving older homeless youth. The project recommends the following: 1) help youth develop and navigate supportive relationships with family, peers, and other caring adults; 2) offer multiple housing options with developmentally appropriate services; 3) guide youth as they connect to mainstream services; and 4) adequately train and support frontline staff.