The National Alliance to End Homelessness and its partners assembled a group of expert practitioners, known as the Practice Knowledge Project, to discuss the most effective interventions to prevent youth homelessness from their experience in the field. This brief provides lessons learned about rapid re-housing programs targeting homeless youth. The project provides the following recommendations to adapt rapid re-housing programs to the youth population: 1) embrace a client-driven, housing first philosophy; 2) actively engage landlords; 3) provide ongoing services and case management; 4) understand programmatic differences for youth versus adult populations; and 5) be flexible in case management, funding, and outcomes.