This report describes practices and services that health care organizations serving people who are homeless have developed to involve homeless youth with systems of care. It provides strategies used by practitioners in the field on how to establish relationships with youth, design services and arrange physical environments, and measure engagement at the individual and agency levels. The authors derived the information outlined in the report from the Engaging Homeless Youth Advisory Work Group, the 2014 National Health Care for the Homeless (HCH) Conference and Policy Symposium, a field survey, interviews with six HCH grantees, and a literature review.