This journal article describes a study to develop the first statewide estimates of known victims and individuals at risk of human trafficking in Ohio. The authors collected data from 12 state and local sources, including child welfare, legal services, and law enforcement records, from 2013 to 2018. From this data collection, they identified 1,032 known victims and 4,209 youth at risk of being trafficking victims during the study period. As an important public health priority, the authors contend researchers can use epidemiological approaches to estimate the prevalence of human trafficking victims and potential victims.