This policy paper from Chapin Hall is an evidence-based guide for the federal government and other stakeholders to prevent and end youth homelessness. The authors recommend a public health approach to emphasize prevention and the need for accountability across systems and society at large. This paper outlines the iterative, multistep process that involved national organizations, federal partners, and young people with lived experience of homelessness to develop 63 recommendations. The authors present these recommendations in the following areas: prevention, crisis response, stable housing, cross-cutting issues, and research and data. (author abstract modified)