This document was developed by fellows of the 2019–2020 Human Trafficking Leadership Academy (HTLA) Class 5 organized through the National Human Trafficking Training and Technical Assistance Center (NHTTAC), Center for Native American Youth (CNAY), and Coro Northern California. Fellows work collaboratively to provide substantive recommendations that will inform research, policies, and programs that improve awareness, understanding, and assistance to survivors of trafficking or those at risk of trafficking. This Class comprises of Indigenous allied professionals and survivor leaders from across the United States, who worked together to respond to the following question: “How can culture be a protective factor in preventing trafficking among Native youth?”. To answer the research question and promote inclusivity, Class 5 fellows reframed it as follows: “How can culture be a protective factor in preventing trafficking among all Indigenous youth?” It is important to acknowledge the inclusivity of all Indigenous youth in this report, including Two-Spirit, Third Gender, LGBTQIA+, girls, boys, Native Americans, Alaska Natives, Native Hawaiians, American Samoans, and so on. This report (1) provides foundational knowledge of historical context and the continued impact on Indigenous communities today and (2) identifies unique vulnerabilities, assets, and strengths found in Indigenous communities and cultures as a means of supporting the recommendations. (author abstract modified)