In this meta-synthesis of current findings on youth interventions, the authors explore common programmatic or contextual factors that researchers and/or practitioners identify as contributing to the successful implementation of an intervention for homeless and unstably housed youth; and (2) that youth and practitioners identify as hindering successful implementation of an intervention for these youth? Two primary themes regarding factors that support successful implementation and engagement were identified: (1) Organizational and system-wide policies can shape the quality and duration of interventions, and (2) Staff behaviors and training are paramount to the success of many interventions. Results further highlight organizational and system-wide policies and staffing behaviors and training needs. The authors conclude that their review supports services that emphasize empowerment and anti-paternalism, and increased attention to racial and LGBTQ equity in future exploration of implementation and engagement within programs designed for youth experiencing homelessness. (author abstract modified)