This report presents the results from a quasi-experimental evaluation by the Urban Institute in multiple Opportunity Works sites across the country. Opportunity Works was a three-year effort in Opportunity Youth Forum communities led by Jobs for the Future to help opportunity youth—young people ages 16 to 24 who are not in school or meaningfully employed—access post-secondary and career pathways. The study found large, consistent, positive effects on participants’ post-secondary enrollment and increased connection with either education or employment about one year after program entry. Specifically, Opportunity Works participants were twice as likely to enroll in college and 25% more likely to be in either education or employment. Post-secondary results were even greater for young men of color, who were nearly six times as likely to enroll in college. This report includes insights and lessons from qualitative field research. (author abstract modified)