This brief from the National Center for Homeless Education (NCHE) provides an overview of the federal Education for Homeless Children and Youth (EHCY) and Runaway and Homeless Youth (RHY) programs and reviews the McKinney-Vento and Runway and Homeless Youth Act requirements related to cross-systems collaboration. NCHE suggests strategies to promote cross-system collaboration to support the education of runaway and homeless youth. The brief includes two partnership profiles and additional resources.