This article describes the study of safe, stable, nurturing relationships (SSNRs) among children and youth in the U.S. using a nationally representative sample of 4,503 children and youth ages 1 month to 17 years. The National Survey of Childrens Exposure to Violence II was designed to obtain up-to-date incidence and prevalence estimates of a wide range of childhood victimizations and information about parenting practices, social support, and stressful life events. To encourage healthy development in children and youth, a better understanding is needed of how exposure to violence and victimization is situated within broader risk contexts as well as those that may be protective or encourage resilience. The authors provide a comprehensive assessment of SSNR factors; examine interrelationships among different indicators of SSNRs; and investigate the consequences of SSNRs for child and adolescent mental health. Results of this study indicate that almost 25 percent of children and adolescents ages 5 to 15 lived in family environments with only moderate levels of safety, stability, and nurturance, while about 1 in 15 had consistently low levels across multiple domains. Lack of SSNRs appears to most heavily burden older adolescents and children living in nontraditional family structures. (Author Abstract-Modified)