The National Network for Youth (NN4Y) released this white paper as a call to action to prevent youth homelessness as a key strategy to also prevent human trafficking given the high rate of co-occurrence. Multiple studies indicate that 19 to 40 percent of youth and young adults experiencing homelessness are also victims of trafficking. The author compiles and summarizes current research about the prevalence of youth homelessness and labor and sex trafficking and discusses some of the common pathways and circumstances that make youth vulnerable to both homelessness and trafficking. The paper outlines the organization’s recommendations for policymakers, educators, youth service providers, and law enforcement to prevent young people from experiencing homelessness or trafficking and specifies what vulnerable youth need to avoid being trafficked.