This paper from the Jim Casey Youth Opportunities Initiative offers recommendations on how to work effectively with youth in or emerging from foster care in the following areas: permanence, educational attainment, economic security, stable housing, and supports for young parents. The paper presents the latest research on adolescent brain development and how to apply this research to promote healthy brain development for youth in foster care. Since 2011, the Jim Casey Youth Opportunities Initiative has led the Success Beyond 18 campaign to raise the age of foster care to 21 years nationwide and to push for foster care that is more supportive of adolescents and emerging adults. The report is intended for child welfare caseworkers and youth service providers, judges, lawyers, caregivers, teachers, coaches, and mentors.